Fellow speaker,
Sometimes things can go a little strange on stage! You arrive andthings aren't quite set up the right way, or there are some delays in getting our handouts passed out, or something else goes wrong. Instead of trying to ignore these things, mention them to the audience, fill the audience in on what the issues are, and then move on. This takes the questions the audience has off the surroundings and focuses them onto your speech!
Refocusing,
Tim